◀ All Modalities

Biologic Modality

Exosomes
& Extracellular Vesicles

Nano-scale lipid vesicles (30-150nm) carrying miRNA, proteins, and growth factors that instruct surrounding cells to repair, reduce inflammation, and regenerate. Acellular — no live cells, no transplant risks. Shelf-stable when lyophilized. Among the most versatile biologics available.

Anti-inflammatory Hair restoration Wound healing Neurology Aesthetics Acellular Shelf-stable
Request Information View Research
30-150
Nanometer size
60+
Growth factors carried
2yr+
Shelf life (lyophilized)
IRB
Largest in biologics

How it works

Mechanism of action

Exosomes do not replace cells. They carry signals that change how existing cells behave — reducing inflammation, stimulating repair, and modulating gene expression at the treatment site and beyond.

01
miRNA Delivery
Exosomes carry microRNA cargo that enters target cells and directly modulates gene expression. A single exosome can carry hundreds of miRNA species, each capable of regulating multiple biological pathways simultaneously — anti-inflammatory, pro-regenerative, anti-fibrotic.
02
Paracrine Signaling
After fusion with target cell membranes, exosome contents activate downstream signaling cascades. Growth factors (VEGF, TGF-beta, PDGF) stimulate nearby cells to proliferate, migrate, and differentiate into repair-active phenotypes.
03
Immunomodulation
MSC-derived exosomes shift macrophages from M1 (pro-inflammatory) to M2 (anti-inflammatory, repair-promoting) phenotype. They suppress T-cell proliferation and reduce pro-inflammatory cytokine production — creating a favorable healing microenvironment.
04
Blood-Brain Barrier Crossing
Unlike most biologics, exosomes can cross the blood-brain barrier due to their nanoscale size and lipid membrane composition. This makes them uniquely suited for neurological applications where other therapeutic modalities cannot reach the target tissue effectively.
05
Angiogenesis
VEGF-carrying exosomes stimulate new blood vessel formation at injury sites, improving oxygen and nutrient delivery. Critical for chronic wound healing, ischemic tissue repair, and hair follicle vascularization in restoration applications.
06
Sustained Release
Lyophilized exosomes reconstitute fully upon rehydration and demonstrate sustained bioactivity. Their lipid membrane protects miRNA and protein cargo from degradation — extending the therapeutic window beyond the injection event itself.

Key distinction

Exosomes vs.
Live Stem Cells

Both deliver therapeutic benefit but through different mechanisms. Understanding the difference helps clinicians and patients choose the right modality for each indication.

Exosomes / EVs
Acellular. Signal only.
✓ No live cells — no transplant risk
✓ Shelf-stable when lyophilized (2yr+)
✓ No cold chain required for lyophilized
✓ Crosses blood-brain barrier
✓ Lower immunogenicity
✓ Highly scalable manufacturing
— No direct cell engraftment or differentiation
MSCs / Stem Cells
Cellular. Engraft and signal.
✓ Direct cell engraftment potential
✓ Multipotent differentiation
✓ Richer structural matrix (WJ products)
— Requires cold chain / cryopreservation
— Higher logistics complexity
— Cannot cross blood-brain barrier directly
— Higher immunogenicity consideration

Many clinicians combine exosomes with WJ-MSCs for synergistic effect — structural matrix from the cells, broad signaling from the exosomes.

Where it works

Clinical Applications

Exosomes are the most versatile biologic modality available. Their ability to cross biological barriers and modulate gene expression makes them effective across a uniquely broad range of specialties.

🧖
Hair Restoration
AGA · Alopecia areata · Follicle stimulation
 ✨
Aesthetics
Skin rejuvenation · Anti-aging · Collagen
 🩹
Wound Healing
Diabetic ulcers · Chronic wounds · Burns
 🧠
Neurological
TBI · Stroke · Parkinson’s · Dementia · MS
 🧎
Joint & OA
Anti-inflammatory · Cartilage support
 🏻
Dermatology
Scar reduction · Skin repair · Psoriasis
 🤰
Reproductive
Endometrial repair · Emerging applications
 ⚽
Sports Medicine
Tendon · Ligament · Soft tissue recovery

Evidence base

Peer-reviewed research on
Exosomes & EVs

Selected from PubMed, PMC, Cureus, and ClinicalTrials.gov. Covering hair restoration, neurology, wound healing, and anti-inflammatory applications.

Meta-analysis
Exosome therapy, PRP, and minoxidil for androgenetic alopecia: a systematic review comparing three modalities
Cureus · 2025 · Darwish et al. · Comparative efficacy analysis across hair restoration modalities
 Review
Exosomes and hair regeneration: a systematic review of clinical evidence across alopecia types and exosome sources
Clinical, Cosmetic and Investigational Dermatology · Sep 2025 · Al Ameer et al. · 11 clinical studies across RCTs, retrospective and prospective designs
 Review
Exosomes as a therapeutic tool to promote neurorestoration and cognitive function in neurological conditions
CNS Neuroscience & Therapeutics · 2024 · Fallahi et al. · Mechanism and clinical evidence for TBI, dementia, Parkinson’s, and stroke applications
 Review
Emerging roles of exosomes in stroke therapy: overcoming the blood-brain barrier and promoting neurological recovery
International Journal of Molecular Sciences · Jun 2024 · Larson et al. · MSC-derived exosome mechanisms in ischemic stroke neuroprotection
 Review
Promises and pitfalls of regenerative therapies for androgenetic alopecia: PRP, photobiomodulation, stem cells, and exosomes
Medical Sciences (MDPI) · 2025 · Gupta, Wang et al. · Scoping review of 5-year clinical evidence across regenerative hair treatments
 Clinical trial
Safety and efficacy of human adipose-derived stem cell exosomes (ADSC-Exo nasal spray) in acute ischemic stroke
ClinicalTrials.gov · NCT07398612 · Enrolling 60 participants 2026-2028 · Phase I/II safety and tolerability study
 Clinical trial
Mechanically engineered UCMSC-derived exosomes vs. conventional exosomes and PRP for endometrial injury repair
ClinicalTrials.gov · NCT06896747 · Active enrolling · WJ-derived exosome preparations vs PRP in reproductive applications
 Review
Exosome-based drug delivery: cancer, infection, neurological and immunological diseases, gene therapy and regenerative medicine
MDPI · 2025 · Comprehensive review of exosome delivery systems including TBI, stroke, and neurodegeneration applications

OurBiologics products

Exosome Product Lines

All products manufactured by Platinum Biologics (Orlando, FL). GMP compliant. AATB accredited. IRB protected. Every lot third-party sterility tested.

Nano AER
50 Billion lyophilized exosomes. Shelf-stable, no refrigeration required. Broad-spectrum anti-inflammatory and regenerative applications.
$500
Nano AER Plus
90 Billion lyophilized exosomes — elevated potency for advanced cases. Same shelf-stable format, higher exosome concentration for complex or chronic presentations.
$750
Nano EX
30 Billion exosomes carrying 60+ growth factors including IL-1RA, TGF-β, and VEGF. Entry-level exosome product for aesthetics and hair restoration protocols.
$250
Nano Xsomes
180 Billion exosomes per mL — ultra-high concentration injectable. Designed for advanced neurological, severe inflammatory, or high-demand regenerative applications.
$1,250
Nano PRP Jelly
70mg Wharton’s Jelly designed for combination with PRP protocols. Delivers exosome-rich matrix alongside PRP growth factors for synergistic hair and tissue restoration.
$150
Combination Protocols
Many clinicians combine Nano AER or Nano Xsomes with Nano Flex (WJ-MSCs) for synergistic effect — structural matrix from the WJ product, broad signaling amplification from exosomes.
Ask your rep

Common questions

Questions about
Exosomes

Exosomes are nano-sized extracellular vesicles (30-150nm) naturally secreted by cells. They function as intercellular messengers — carrying proteins, lipids, and RNA (including microRNA) that modify the behavior of recipient cells. MSC-derived exosomes carry the therapeutic signaling cargo responsible for most of the benefit associated with stem cell therapies, without requiring the live cells themselves.
Exosomes are acellular — they contain no live cells. This eliminates risks associated with cell transplantation such as uncontrolled proliferation, immune rejection of foreign cells, or tumorigenicity. They also show lower immunogenicity than cellular products. However, “safer” depends on the indication — for some applications, the structural and differentiation capacity of live MSCs provides benefits that exosomes alone cannot replicate.
The blood-brain barrier (BBB) is designed to restrict passage of large molecules and cells from the bloodstream into the brain. Exosomes are small enough (30-150nm) and have a lipid membrane composition that allows them to traverse the BBB through transcytosis — the same process the brain uses to transport essential molecules. This makes them uniquely suited for neurological applications where most other biologics cannot reach the target tissue.
Lyophilized (freeze-dried) exosomes are shelf-stable at room temperature for 2+ years. This eliminates the cold chain requirements of frozen products, allows point-of-care storage, and simplifies overnight shipping logistics. Biological activity is fully preserved through the lyophilization process. Upon reconstitution with sterile saline, they are ready for immediate clinical use.
The evidence base is growing rapidly. A 2025 systematic review covering 11 clinical studies found exosome therapy demonstrated improvements in hair density and thickness across androgenetic alopecia and other alopecia types, with no significant adverse reactions reported. ADSC-derived exosomes applied topically showed meaningful results in 39 AGA patients in early clinical work. The current consensus is that exosomes show strong promise but require more large-scale RCTs to establish standardized protocols.
Product selection depends on indication and case complexity. Nano EX (30B) is a starting point for aesthetics and hair. Nano AER (50B) is the standard for most anti-inflammatory and regenerative applications. Nano AER Plus (90B) is for complex or advanced cases. Nano Xsomes (180B/mL) is the highest concentration for neurological or severe inflammatory applications. Your OurBiologics representative can walk you through protocol recommendations for your specific specialty. Contact us for a 10-minute consultation.

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Section 361 HCT/P · AATB Accredited · IRB Protected
Important Regulatory Notice

Exosome products offered through Our Biologics Distributors are human cellular and tissue-based products (HCT/Ps) regulated under FDA 21 CFR Part 1271, Section 361 — not FDA-approved drug products. They are minimally manipulated, acellular, and manufactured in compliance with AATB accreditation standards and GMP guidelines.

These products have not been evaluated by the FDA for safety or efficacy for any specific indication. They are not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Clinicians are responsible for independent evaluation of suitability for each patient. This material is intended for licensed healthcare professionals only.

Our Biologics Distributors
© 2026 Our Biologics Distributors · Powered by Platinum Biologics, Orlando, FL.
Products are not FDA approved or licensed to treat, cure, or prevent any disease.